Paradoxical shortening of scrapie incubation times by expression of prion protein transgenes derived from long incubation period mice
作者： David Westaway , Carol A. Mirenda , Dallas Foster , Yeganeh Zebarjadian , Michael Scott
DOI: 10.1016/0896-6273(91)90074-A
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摘要: Abstract Prolonged incubation times for experimental scrapie in ILnJ mice are dictated by a dominant gene linked to the prion protein ( Prn-p ). Transgenic were analyzed discriminate between an effect of b allele and distinct time locus designated Prn-i . Paradoxically, 4 independent transgenic mouse lines had shorter than nontransgenic controls, instead anticipated prolonged periods. Aberrant or over-expression transgenes may dictate abbreviated times, masking genuine PrnpPrn-i congruence; alternatively, discrete lies adjacent
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