Feeding response to melanocortin agonist predicts preference for and obesity from a high-fat diet.

摘要: Overconsumption and increased selection of high fat (HF) foods contribute to the development common obesity. Because hypothalamic melanocortin (MC) system plays an integral role in regulation food intake dietary choice, we tested hypothesis that proneness (-P) or resistance (-R) dietary-induced obesity (DIO) may be due differences MC function. We found prior developing while still maintained on chow, acute, central administration MTII, agonist, produced a greater anorectic response DIO-P rats than DIO-R rats. However, after only 5 days exclusive HF feeding, had significantly suppression MTII treatment they did when chow. In addition, were much less responsive diet. fact, MTII-induced anorexia during feeding correlated negatively with body weight gained These results suggest voluntary decrease mediated by endogenous signaling, signal likely compromised Differences also explain observed preference for over lower choice Finally, indicate responses exogenous challenge can used predict DIO.