Is carrot consumption associated with a decreased risk of lung cancer? A meta-analysis of observational studies.

摘要: Findings of epidemiological studies regarding the association between carrot consumption and lung cancer risk remain inconsistent. The present study aimed to summarise current evidence concerning intake with a meta-analysis. We conducted meta-analysis case-control prospective cohort studies, searched PubMed Embase databases from their inception April 2018 without restriction by language. also reviewed reference lists included articles. Prospective or reporting OR relative corresponding 95 % CI for highest compared lowest category intake. A total eighteen eligible (seventeen one study) were included, involving 202 969 individuals 5517 patients cancer. pooled was 0·58 (95 0·45, 0·74) comparing consumption. Based on subgroup analyses types cancer, we that squamous cell carcinoma (OR 0·52, 0·19, 1·45), small-cell 0·43, 0·12, 1·59), adenocarcinoma 0·34, 0·15, 0·79), large-cell 0·40, 0·10, 1·57), 0·85, 1·62), 0·20, 0·02, 1·70) mixed 0·61, 0·46, 0·81). Exclusion any single did not materially alter OR. Integrated observational supported hypothesis may decrease especially adenocarcinoma.