Novel Epigenetic Biomarkers for the Barrett’s – Adenocarcinoma Sequence in Oesophageal Cancer

摘要: Introduction Oesophageal adenocarcinoma presents an ever increasing challenge to the NHS, with rising incidence and poor overall survival. There are few robust biomarkers available for this disease – either detection or stratification. Barrett’s Oesophagus, a precursor adenocarcinoma, is common. In non-dysplastic setting, patients will progress cancer. no current aid in stratification process. Aims To assess role of methylation context diagnosis their tumour biology. To provide tool identification high risk Oesophagus. Methods Genome wide assessment was performed validation using bisulphite pyrosequencing on carefully selected tissues reveal novel biomarkers Results Methylation TRIM15, has been shown be biomarker biology. OR3A4, long none coding RNA, identified as way reliably stratify patient forms first kind. Conclusions Methylation play key cancer development. They also appear