Effects of dimethyl carbonate-induced autophagic activation on follicular development in the mouse ovary

摘要: Dimethyl carbonate (DMC) is a widely used industrial chemical, which may be increasingly in the future. However, its toxicity profile remains largely unknown. The present study was designed to investigate effects of DMC exposure on ovaries and effect autophagy activation follicular development. Rats were randomly divided into control group low, medium high dose groups (all n=10). Histological analyses identified no marked differences rate apoptosis between low groups; however, occurred groups. expression cleaved caspase-3 significantly increased groups, consistent with changes observed Bcl-2 Bax. These results indicated that induces ovarian function via induction apoptosis. autophagy-related proteins light chain 3II, beclin-1 p62 following further activated primarily granulosa cells follicles dose-dependent manner. In addition, hypoxia inducible factor 1 α subunit (HIF-1α) target protein BCL2 interacting 3 (BNIP3) they serve role development process induced by DMC. current demonstrated tissue. Furthermore, doses protect activating HIF-1α/BNIP3 signaling pathway. Taken together, these indicate atresia apoptotic This an important mechanism regulating mammals.