Web-based accurate measurements of carotid lumen diameter and stenosis severity: An ultrasound-based clinical tool for stroke risk assessment during multicenter clinical trials

摘要: Abstract Background This pilot study presents a completely automated, novel, smart, cloud-based, point-of-care system for (a) carotid lumen diameter (LD); (b) stenosis severity index (SSI) and (c) total area (TLA) measurement using B-mode ultrasound. The proposed was (i) validated against manual reading taken by the Neurologist (ii) benchmarked commercially available system. Method One hundred patients (73 M/27 F, mean age: 68 ± 11 years), institutional review board approved, written informed consent, consisted of left/right common artery (200 ultrasound scans) were acquired 7.5-MHz linear transducer. Results measured LD left right carotids (in mm): (6.49 ± 1.77, 6.66 ± 1.70); (6.29 ± 1.79, 6.45 ± 1.63), respectively coefficient correlation between cloud-based automated 0.98 (P  AUC receiving operating characteristics was: 1.0. Four statistical tests such as: Two-tailed z-test, Mann-Whitney test, Kolmogorov-Smirnov (KS) one-way ANOVA performed to demonstrate consistency reliability. Conclusions is reliable, accurate, fast, anytime-anywhere solution multi-center clinical trials routine vascular screening.