Phytochemical variation in Canadian Hydrastis canadensis L (goldenseal) and the in vitro inhibition of human cytochrome P450-mediated drug metabolism by H canadensis and other botanicals

摘要: To promote recovery and crop potential of Hydrastis canadensis – a botanical threatened in Canada – wild populations were phytochemically surveyed. Berberine, hydrastine canadine characterized root-rhizome, stem-leaf, berry pulp. Comparisons with cultivated material showed no difference alkaloid content, thus the medicinal value is not likely increased addition plants. Quantitative analyses suggested genetic diversity among populations. Regression indicated minor relationship between latitude yield. Because H. canadensis other botanicals may cause adverse botanical-drug interactions, 22 assayed for cytochrome P450 (CYP) 2C19, CYP3A4 CYP19 inhibition. Eight inhibited CYP2C19 by ≥ 57%, 17 40% 50%, which Arctostaphylos uva-ursi, H canadensis, Oenothera biennis, Rhodiola rosea Sanguinaria most potent. berberine concentration was significant factor