Human Papillomavirus Laboratory Testing: the Changing Paradigm

摘要: High-risk human papillomaviruses (HPVs) cause essentially all cervical cancers, most anal and oropharyngeal some vaginal, vulvar, penile cancers. Improved understanding of the pathogenesis infection availability newer tests are changing approach to screening diagnosis. Molecular detect DNA from common high-risk HPVs FDA approved for use in conjunction with cytology cancer programs. More-specific that RNA HPV types now also available. The molecular as primary is being adopted areas. Genotyping identify HPV16 -18 has a recommended role triaging patients colposcopy who positive but have normal cytology. There currently no methods anal, penile, or infections. testing limited utility at high risk cancer, p16 immunohistochemistry clarify lesions tissue biopsy specimens show moderate dysplasia precancer mimics. squamous cell tumors prognostic indicator. Ongoing research will help improve content future guidelines diagnostic testing.