Severe falciparum malaria in young children of the Kassena-Nankana district of northern Ghana.

摘要: Severe falciparum malaria in children was studied as part of the characterization Kassena-Nankana District Ghana for future vaccine trials. Children aged 6–59 months with diagnosis suggestive acute disease were characterized using standard WHO definition severe malaria. Of total screened, 45.2% (868/1921) satisfied criteria Estimated incidence 3.4% (range: 0.4–8.3%) cases per year. The seasonal: 560 year, which 70.4% occurred during wet season (June-October). main manifestations anaemia (36.5%); prolonged or multiple convulsions (21.6%); respiratory distress (24.4%) and cerebral (5.4%). Others hyperpyrexia (11.1%); hyperparasitaemia (18.5%); hyperlactaemia (33.4%); hypoglycaemia (3.2%). frequency 39.8% six to 24 age 25.9% 25–60 age. More (8.7%) group had compared 4.4% 6–24 group. overall case fatality ratio 3.5%. Cerebral hyperlactataemia significant risk factors associated death. anaemia, though a major presentation, not significantly is frequent seasonal childhood northern maybe an adequate endpoint