Quantification of brain gray matter damage in different MS phenotypes by use of diffusion tensor MR imaging.

摘要: BACKGROUND AND PURPOSE: Increasing evidence exists that cerebral gray matter (GM) from patients with multiple sclerosis (MS) is not spared. This study was performed to quantify in vivo the extent of GM pathologic abnormality relapsing-remitting (RR), secondary progressive (SP), and primary MS, by using diffusion tensor (DT) MR imaging. METHODS: Dual-echo DT imaging brain were 102 MS 30 healthy volunteers. After segmentation a technique based on anisotropy thresholding, average diffusivity (D) histograms produced for all participants. RESULTS: All D histogram-derived metrics significantly different between control volunteers whole population. No significant difference found any RRMS, whereas differences histogram peak location PPMS. differed RRMS SPMS. Patients SPMS also had lower than did strongly correlated T2 lesion volume. CONCLUSIONS: confirms presence changes MS. It shows such greater during forms disease.