Essential proteins and possible therapeutic targets of Wolbachia endosymbiont and development of FiloBase-a comprehensive drug target database for Lymphatic filariasis

摘要: Lymphatic filariasis (Lf) is one of the oldest and most debilitating tropical diseases. Millions people are suffering from this prevalent disease. It estimated to infect over 120 million in at least 80 nations world through subtropical regions. More than billion danger getting affected with life-threatening Several studies were suggested its emerging limitations resistance towards available drugs therapeutic targets for Lf. Therefore, better medicine drug demand. We took an initiative identify essential proteins Wolbachia endosymbiont Brugia malayi, which indispensable their survival non-homologous human host proteins. In current study, we have used proteome subtractive approach screen possible wBm. addition, numerous literatures mined hunt potential targets, drugs, epitopes, crystal structures, expressed sequence tag (EST) sequences filarial causing nematodes. Data obtained our study presented a user friendly database named FiloBase. hope that information stored may be further research development process against filariasis. URL: http://filobase.bicpu.edu.in.