PROTECTIVE EFFECT OF LACTOBACILLUS ACIDOPHILUS AND SACCHAROMYCES CEREVISIAE AGAINST MULTI-DRUG RESISTANT SALMONELLA ENTERICA SEROVAR TYPHIMURIUM IN VITRO AND IN VIVO

作者: Safa K. Ibraheem , Abdulwahid B. Alshaibani

DOI:

关键词:

摘要: It was aimed to investigate anti-bacterial effects of two probiotics (Lactobacillus acidophilus and Saccharomyces cerevisiae) against MDR isolate S. Typhimurium in vitro vivo by using the mouse as an animal model infection. Accordingly, five groups mice were established. In group I, received probiotic for 7 successive days, challenged with on day 8, dissected days 14 21. Group II similarly treated, but continued days. III given a only; IV Typhimurium, while V controls. By filtrates at one-fold, two-fold three-fold concentration, it found that filtrate recorded highest inhibition zone both (S. cerevisiae L. acidophilus), which 25.0 ± 1.0 31.0 mm, respectively. Also, effective reducing colony forming units per plate (CFU/plate) liver spleen. liver, showed count 224.4 7.26 CFU/plate, significantly higher than any CFU cerevisiae. better results I mice, lowest observed 21, 21.6 627 27.8 0121 respectively The strongly suggest anti-Salmonella probiotics.

参考文章(28)
Praveen Rishi, Swapandeep Kaur Mavi, Sushma Bharrhan, Geeta Shukla, Rupinder Tewari, Protective efficacy of probiotic alone or in conjunction with a prebiotic in Salmonella-induced liver damage. FEMS Microbiology Ecology. ,vol. 69, pp. 222- 230 ,(2009) , 10.1111/J.1574-6941.2009.00703.X
S F Barefoot, T R Klaenhammer, Detection and activity of lactacin B, a bacteriocin produced by Lactobacillus acidophilus. Applied and Environmental Microbiology. ,vol. 45, pp. 1808- 1815 ,(1983) , 10.1128/AEM.45.6.1808-1815.1983
J.-C. Piard, P. M. Muriana, M. J. Desmazeaud, T. R. Klaenhammer, Purification and Partial Characterization of Lacticin 481, a Lanthionine-Containing Bacteriocin Produced by Lactococcus lactis subsp. lactis CNRZ 481. Applied and Environmental Microbiology. ,vol. 58, pp. 279- 284 ,(1992) , 10.1128/AEM.58.1.279-284.1992
Patrice Cani, Nathalie Delzenne, The role of the gut microbiota in energy metabolism and metabolic disease. Current Pharmaceutical Design. ,vol. 15, pp. 1546- 1558 ,(2009) , 10.2174/138161209788168164
Hakan Akin, Nurdan Tözün, Diet, microbiota, and colorectal cancer. Journal of Clinical Gastroenterology. ,vol. 48, ,(2014) , 10.1097/MCG.0000000000000252
Ahmad Cheikhyoussef, Natascha Pogori, Wei Chen, Hao Zhang, Antimicrobial proteinaceous compounds obtained from bifidobacteria: From production to their application International Journal of Food Microbiology. ,vol. 125, pp. 215- 222 ,(2008) , 10.1016/J.IJFOODMICRO.2008.03.012