The von Hippel–Lindau Protein, Vascular Endothelial Growth Factor, and Kidney Cancer

摘要: Early in the 20th century, it was hypothesized that solid tumors secrete factors, now referred to as angiogenic induce angiogenesis — formation of new blood vessels thereby ensuring delivery enough support growth tumor. The idea inhibiting would have an antitumor effect has been borne out by startling anticancer activity some antiangiogenic agents tumor-bearing mice. For these reasons, perhaps no area cancer research attracted much attention, both on Main Street and Wall Street, angiogenesis. Unfortunately, dramatic effects . . .