The myofibroblast: a study of normal, reactive and neoplastic tissues, with an emphasis on ultrastructure. Part 1--normal and reactive cells

摘要: The myofibroblast is essential for the integrity of mammalian body by virtue its role in wound-healing, but it can also threaten ability to promote tumour progression. It an almost universal cellular component lesions, not a typical normal untraumatised tissues. Partly because absence from tissue, has been part conventional histology teaching. This contributed difficulties appreciating nature and defining scientists interested mechanism disease pathologists wanting diagnose myofibroblastic rumours. paper documents features with emphasis on ultrastructure. A base-line understanding first provided description cells found tissues, which occasion postulated as arising, or which, varying degrees, confused--fibroblasts, smooth-muscle cells, endothelium, pericytes, myoepithelium lymphoid reticulum cells. biology, light microscopy ultrastructure are then documented comparison. Features emphasised include: spindled cell morphology, abundant matrix, immunostaining alpha-smooth-muscle actin (in desmin h-caldesmon) ED-A splice variant fibronectin, rough endoplasmic reticulum, peripherally located type myofilaments, Golgi apparatus producing collagen-secretion granules, gap junctions fibronexus junctions. distinctive organelle identifying lamina absent. myofibroblasts arise granulation tissue progression discussed briefly, appendix provides summaries involvement non-neoplastic diseases.