摘要: Functional genomics represents a systematic approach to elucidating the function of novel genes revealed by complete genome sequences. Such an should adopt hierarchical strategy since this will both limit number experiments be performed and permit closer approximation any individual gene achieved. Moreover, analyses have, in their early stages, tremendous integrative power functional aims at comprehensive view workings living cells. The first draft human sequence has just been produced, sequences eukaryotic pathogens (including parasitic protozoa Plasmodium, Leishmania, Trypanosoma) soon available. However, most rapid progress elucidation initially made using model organisms. Yeast is excellent least 40% single-gene determinants heritable diseases find homologues yeast. We have adopted analysis Saccharomyces cerevisiae genome. A approaches for yeast are discussed. different grouped into four domains: genome, transcriptome, proteome, metabolome. utility genetic, biochemical, physico-chemical methods these domains discussed, importance framing precise biological questions, when analytical methods, emphasized. Finally, prospects protozoan pioneered with yeast, even exploiting itself, as surrogate, explored.
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