Non-classic EGFR mutations in a cohort of Dutch EGFR-mutated NSCLC patients and outcomes following EGFR-TKI treatment
作者： J L Kuiper , S M S Hashemi , E Thunnissen , P J F Snijders , K Grünberg
DOI: 10.1038/BJC.2016.372
关键词:
摘要: Data on non-small-cell lung cancer (NSCLC) patients with non-classic epidermal growth factor receptor (EGFR) mutations are scarce, especially in non-Asian populations. The purpose of this study was to evaluate prevalence, clinical characteristics and outcome EGFR-TKI treatment according type EGFR mutation a Dutch cohort NSCLC patients. We retrospectively evaluated 240 EGFR-mutated demographics, tumour-related features, were collected compared between classic mutations, exon 20 insertions other uncommon mutations. Classic detected 186 (77.5%) 54 (22.5%); 23 an insertion (9.6%) 31 (12.9%). Median progression-free survival (PFS) overall (OS) 2.9 9.7 months, respectively, for insertion, 6.4 20.2 mutation. Patients double that included G719X/L861Q/S768I had longer PFS OS single (both P=0.02). In our cohort, prevalence genotype distribution accordance previously reported data. shorter but varied among different
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E. Stone, H. A. Allen, T. Saghaie, A. Abbott, R. Daniel, R. S. Mead, M. Kohonen-Corish, M. Plit, L. Morgan, High proportion of rare and compound epidermal growth factor receptor mutations in an Australian population of non‐squamous non‐small‐cell lung cancer Internal Medicine Journal. ,vol. 44, pp. 1188- 1192 ,(2014) , 10.1111/IMJ.12587
Hidefumi Sasaki, Katsuhiko Endo, Minoru Takada, Masaaki Kawahara, Naoto Kitahara, Hisaichi Tanaka, Meinoshin Okumura, Akihide Matsumura, Keiji Iuchi, Tomoya Kawaguchi, Osamu Kawano, Haruhiro Yukiue, Tomoki Yokoyama, Motoki Yano, Yoshitaka Fujii, EGFR exon 20 insertion mutation in Japanese lung cancer Lung Cancer. ,vol. 58, pp. 324- 328 ,(2007) , 10.1016/J.LUNGCAN.2007.06.024
A G Pallis, A Voutsina, Ar Kalikaki, J Souglakos, E Briasoulis, S Murray, A Koutsopoulos, M Tripaki, E Stathopoulos, D Mavroudis, V Georgoulias, ‘Classical’ but not ‘other’ mutations of EGFR kinase domain are associated with clinical outcome in gefitinib-treated patients with non-small cell lung cancer British Journal of Cancer. ,vol. 97, pp. 1560- 1566 ,(2007) , 10.1038/SJ.BJC.6604068
Tetsuya Mitsudomi, Yasushi Yatabe, Mutations of the epidermal growth factor receptor gene and related genes as determinants of epidermal growth factor receptor tyrosine kinase inhibitors sensitivity in lung cancer Cancer Science. ,vol. 98, pp. 1817- 1824 ,(2007) , 10.1111/J.1349-7006.2007.00607.X
Susumu Kobayashi, Hannah M. Canepa, Alexandra S. Bailey, Sohei Nakayama, Norihiro Yamaguchi, Michael A. Goldstein, Mark S. Huberman, Daniel B. Costa, Compound EGFR mutations and response to EGFR tyrosine kinase inhibitors. Journal of Thoracic Oncology. ,vol. 8, pp. 118- 122 ,(2013) , 10.1097/JTO.0B013E3182781E35
Tommaso De Pas, Francesca Toffalorio, Michela Manzotti, Caterina Fumagalli, Gianluca Spitaleri, Chiara Catania, Angelo Delmonte, Monica Giovannini, Lorenzo Spaggiari, Filippo de Braud, Massimo Barberis, Activity of Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors in Patients with Non-small Cell Lung Cancer Harboring Rare Epidermal Growth Factor Receptor Mutations Journal of Thoracic Oncology. ,vol. 6, pp. 1895- 1901 ,(2011) , 10.1097/JTO.0B013E318227E8C6
Akito Hata, Hiroshige Yoshioka, Shiro Fujita, Kei Kunimasa, Reiko Kaji, Yukihiro Imai, Keisuke Tomii, Masahiro Iwasaku, Akihiro Nishiyama, Tadashi Ishida, Nobuyuki Katakami, Complex Mutations in the Epidermal Growth Factor Receptor Gene in Non-small Cell Lung Cancer Journal of Thoracic Oncology. ,vol. 5, pp. 1524- 1528 ,(2010) , 10.1097/JTO.0B013E3181E8B3C5
Chris M.J. Conklin, Kenneth J. Craddock, Cherry Have, Janessa Laskin, Christian Couture, Diana N. Ionescu, Immunohistochemistry is a reliable screening tool for identification of ALK rearrangement in non-small-cell lung carcinoma and is antibody dependent. Journal of Thoracic Oncology. ,vol. 8, pp. 45- 51 ,(2013) , 10.1097/JTO.0B013E318274A83E
E.A. Eisenhauer, P. Therasse, J. Bogaerts, L.H. Schwartz, D. Sargent, R. Ford, J. Dancey, S. Arbuck, S. Gwyther, M. Mooney, L. Rubinstein, L. Shankar, L. Dodd, R. Kaplan, D. Lacombe, J. Verweij, New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1) European Journal of Cancer. ,vol. 45, pp. 228- 247 ,(2009) , 10.1016/J.EJCA.2008.10.026
Toshihiko Yokoyama, Masashi Kondo, Yasuhiro Goto, Takayuki Fukui, Hiromu Yoshioka, Kohei Yokoi, Hirotaka Osada, Kazuyoshi Imaizumi, Yoshinori Hasegawa, Kaoru Shimokata, Yoshitaka Sekido, EGFR point mutation in non-small cell lung cancer is occasionally accompanied by a second mutation or amplification. Cancer Science. ,vol. 97, pp. 753- 759 ,(2006) , 10.1111/J.1349-7006.2006.00233.X