Gene Therapy for Chronic Pain

摘要: Gene therapy shows great potential to assist numerous patients with inadequate relief of inflammatory or neuropathic pain, intractable pain associated advanced cancer. A brief overview is provided the methods gene and preclinical findings in animal models prolonged inflammatory, cancer pain. Preclinical demonstrate no efficacy on basal thermal nociception mechanical sensitivity, almost universal effects pathological hypersensitivity models. The status human trials recommendations for future directions precautions. This early stage development chronic will likely be followed by an increased number clinical aimed specifically at chronic, unrelenting