HLA class II DRB1, DQB1 and DPB1 genotypic associations with peanut allergy: evidence from a family-based and case-control study.

摘要: Background Peanut is one of the most common foods provoking allergic reactions and frequent cause fatal near-fatal food-induced anaphylaxis. However, as yet, little known genetic immunological mechanisms which underly peanut allergy. Objective Based on findings in other diseases, we have investigated whether particular human leucocyte antigen (HLA) class II polymorphisms contribute to development Methods All individuals from 37 families each containing or more individuals, plus nine unrelated patients (161 total, defined study group) were typed for HLA DRB1, DQB1 DPB1 loci, by PCR-based techniques. Genotype frequencies compared with those found 293 controls. Results Four genotypes (DRB1*08 (13.7% vs 4.8%; Pc = 0.026), DRB1*08/12 tyr 16 (22.4% 8.2%; 0.021), DQB1*04 (12.2% 2.7%; 0.0026) DPB1*0301 (49.1 22.5%; 0.00062)) present at a significantly higher frequency group Three these (18.0%; 0.027), tyr16 (24.0%; 0.029) (16.7%; 0.0029)) also increased In addition, two (DPB1*0101 0201) decreased overall group, but not specifically individuals. Conclusion While factors may be important, results this indicate that polymorphism play role determining susceptibility