The double-edged sword of long non-coding RNA: The role of human brain-specific BC200 RNA in translational control, neurodegenerative diseases, and cancer
作者： Patrycja Sosińska , Justyna Mikuła-Pietrasik , Krzysztof Książek
DOI: 10.1016/J.MRREV.2015.08.002
关键词:
摘要: The complexity of eukaryotic organisms involves the regulation gene expression through DNA-protein, RNA-DNA, RNA-RNA, and RNA-protein interactions. role RNA molecules in genes higher species has become even more evident with discovery that about 97% transcription products are represented by non-protein coding RNAs (ncRNAs) including short ncRNAs long (lncRNAs). In addition to well-characterized different physiological cellular processes, numerous studies have also indicated crucial roles neurological diseases cancer. Although involvement ncRNA those pathologies already been well documented, there is only scarce evidence show participation lncRNAs. One examples lncRNAs BC200 RNA, which plays an important dendritic protein expression. Mislocalization overexpression leads inadequate delivery synapses results neurodegenerative processes Alzheimer's disease neoplastic changes various groups tissues. this review, we summarize current state art field biological significance lncRNAs, particular attention paid pathophysiological RNA.
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