Putting the efficacy of psychiatric and general medicine medication into perspective: review of meta-analyses

作者: Stefan Leucht , Sandra Hierl , Werner Kissling , Markus Dold , John M. Davis

DOI: 10.1192/BJP.BP.111.096594

关键词:

摘要: Background The efficacy of psychopharmacological treatments has been called into question. Psychiatrists are unfamiliar with the effectiveness common medical drugs. Aims To put psychiatric drugs perspective that major drugs. Method We searched Medline and Cochrane Library for systematic reviews on compared placebo disorders, systematically presented effect sizes primary outcomes. Results included 94 meta-analyses (48 in 20 diseases, 16 8 disorders). There were some general clearly higher than psychotropic agents, but not generally less efficacious other drugs. Conclusions Any comparison different outcomes diseases can only serve purpose a qualitative perspective. The increment improvement by drug over must be viewed context disease’s seriousness, suffering induced, natural course, duration, outcomes, adverse events societal values.

参考文章(178)
Sally SA Burgess, John Geddes, Keith KE Hawton, Matthew J Taylor, Ellen Townsend, K Jamison, Guy Goodwin, Lithium for maintenance treatment of mood disorders. Cochrane Database of Systematic Reviews. ,(2001) , 10.1002/14651858.CD003013
Rekha Garg, Salim Yusuf, WD Bussmann, Peter Sleight, Andrew Uprichard, Barry Massie, Barry McGrath, Berit Nilsson, Bertram Pitt, Bruno Magnani, Carol Maskin, Ettore Ambrosioni, Ewa Rucinska, Franz X Kleber, Gary Jennings, Gianni Tognoni, Helmut Drexler, John GF Cleland, Joseph A Franciosa, Jouko Remes, Karl Swedberg, Kenneth Dickstein, Lothar Maass, Marc Pfeffer, Mark A Creager, Maryann Gordon, Michael Joy, Norman Sharpe, Pierre Desche, Robin McGarry, Rory Collins, Steven G Chrysant, Vincenzo Cicchetti, Overview of Randomized Trials of Angiotensin-Converting Enzyme Inhibitors on Mortality and Morbidity in Patients With Heart Failure JAMA: The Journal of the American Medical Association. ,vol. 273, pp. 1450- 1456 ,(1995) , 10.1001/JAMA.1995.03520420066040
Levodopa and the progression of Parkinson's disease. The New England Journal of Medicine. ,vol. 351, pp. 2498- 2508 ,(2004) , 10.1056/NEJMOA033447
Maria E Suarez-Almazor, Carol Spooner, Elaine Belseck, Beverley Shea, Auranofin versus placebo in rheumatoid arthritis. Cochrane Database of Systematic Reviews. ,(2000) , 10.1002/14651858.CD002048
Anna Ceraso, Jessie Jingxia Lin, Johannes Schneider-Thoma, Spyridon Siafis, Magdolna Tardy, Katja Komossa, Stephan Heres, Werner Kissling, John M Davis, Stefan Leucht, Maintenance treatment with antipsychotic drugs for schizophrenia Cochrane Database of Systematic Reviews. ,vol. 8, ,(2012) , 10.1002/14651858.CD008016.PUB2
Muireann Ni Chroinin, Ilana IG Greenstone, Francine Ducharme, Vincent Masse, A Danish, Long-acting beta2-agonists versus placebo in addition to inhaled corticosteroids in children and adults with chronic asthma. Cochrane Database of Systematic Reviews. ,(2005) , 10.1002/14651858.CD005535
Paul A Heidenreich, Tina T Lee, Barry M Massie, Effect of beta-blockade on mortality in patients with heart failure: a meta-analysis of randomized clinical trials. Journal of the American College of Cardiology. ,vol. 30, pp. 27- 34 ,(1997) , 10.1016/S0735-1097(97)00104-6
Jesper Brok, Lise Lotte Gluud, Christian Gluud, Ribavirin plus interferon versus interferon for chronic hepatitis C. Cochrane Database of Systematic Reviews. ,(2010) , 10.1002/14651858.CD005445.PUB2
George PA Rice, Barbara Incorvaia, Luca M. Munari, George Ebers, Chris Polman, Roberto D'Amico, Elena Parmelli, Graziella Filippini, Interferon in relapsing-remitting multiple sclerosis. Cochrane Database of Systematic Reviews. ,vol. 2001, ,(2001) , 10.1002/14651858.CD002002