Real-time optoacoustic monitoring of temperature in tissues

摘要: To improve the safety and efficacy of thermal therapy, it is necessary to map tissue temperature in real time with submillimetre spatial resolution. Accurate maps may provide control boundaries heated regions minimize damage surrounding normal tissues. Current imaging modalities fail monitor high resolution accuracy. We investigated a non-invasive optoacoustic method for accurate, real-time monitoring during thermotherapy. In this study, we induced gradients tissue-like samples monitored distribution using technique. The fundamental harmonic Q-switched Nd : YAG laser (λ = 1064 nm) was used wave generation probing temperature. also multi-sensor probe inserted samples. Good agreement between optoacoustically measured actual temperatures obtained. accuracy better than 1°C, while about 1 mm. These data suggest that technique has potential be non-invasive,