Anti-endothelial cell antibodies (AECA) in patients with systemic vasculitis: our research using proteomics

摘要: Importance of the field: Anti-endothelial cell antibodies (AECA) may cause damage to endothelial (EC) functions and therefore be a pathophysiological role in systemic vasculitis. The AECA, however, is still uncertain. Areas covered this review: To clarify detailed roles various methods for identification target proteins AECA have been developed, such as expression libraries proteomic approaches combining two-dimensional electrophoresis immunoblotting. What reader will gain: Advances, including our research, made defining antigens which we summarize review. Furthermore, discuss possible significance pathophysiology vascular value Take home message: identify establish standardized method measuring would helpful search sys...