Comparison of force and stiffness in normal and dystrophic mouse muscles.

摘要: Isometric force and stiffness of fast- slow-twitch muscles affected normal mice the 129/ReJ dy/dy strain were studied at rest during active contraction a variety lengths. Dystrophic developed less in response to stimulation, but resting was not reduced as much, particularly long muscle This is consistent with replacement fibers by connective tissue that considerably elastic. When second third stimuli are superimposed on rising phase twitch muscle, less-than-linear summation generation (early depression) followed more-than-linear (later facilitation). showed smaller early depression greater later facilitation stiffness. Many these phenomena can be predicted from simple model Ca2+ release binding troponin.