Biological predictors of lithium response in bipolar disorder

摘要: Abstract In order to prescribe lithium appropriately patients with bipolar disorder, predictors of response are helpful. The present paper reviews the biological response. As a positive predictor response, following have been reported: strong loudness dependence auditory-evoked N1/P2-response; higher brain concentration; lower inositol monophosphatase (IMPase) mRNA expression; serotonin-induced calcium mobilization; increased N-acetyl-aspartate peak and decreased myo-inositol peak; white matter hyperintensity; intracellular pH; frequency phospholipase C γ-1 (PLCG1)-5 repeat PLCG1-8 repeat; C973A polymorphism in polyphosphate 1-phosphatase gene. contrast reported as negative response: epileptiform abnormality electroencephalography; human leukocyte antigen type A3; phosphocreatine area after photic stimulation; homozygotes for short variant serotonin transporter Most possible better such IMPase levels, hyperintensity, pH, enhanced PLCG1-5 had detected risk factors suggesting that disorder responding well maintenance treatment is distinct category having certain neurobiological basis, although these findings need further replication. search still its infancy. laboratory or neuroimaging techniques used studies not easily performed clinical settings, so development an easy useful test needed.