Development of a quality-of-life instrument for autoimmune bullous disease: The autoimmune bullous disease quality of life questionnaire

摘要: Importance Quality-of-life (QOL) evaluation is an increasingly important outcome measure in dermatology, with disease-specific QOL instruments being the most sensitive to changes disease status. Objective To develop a instrument specific autoimmune bullous (AIBD). Design A comprehensive item generation process was used build 45-item pilot Autoimmune Bullous Disease Quality of Life (ABQOL) questionnaire, distributed 70 patients AIBD. Experts refined ABQOL before factor analysis performed yield final questionnaire 17 questions. We evaluated validity and reliability across range indices. Setting Australian dermatology outpatient clinics private practices. Patients Exposure histological diagnosis Main Outcomes Measures The development AIBD-specific instrument. Results Face content were established through patient interview expert review. In terms convergent validity, found have moderate correlation scores on Dermatology Index ( R  = 0.63) General Health subscale 36-Item Short Form Survey  = 0.69; P  = .009) low Pemphigus Area  = 0.42) Skin Disorder Intensity Score  = 0.48). discriminant be more than  = .02). also reliable by internal consistency (Cronbach α coefficient, 0.84) test-retest (mean percentage variation, 0.92). Conclusions Relevance has been shown valid that may serve as end point clinical trials. Future work should include incorporating weighting questions further increase translation other languages. Clinical Trial Registration anzctr.org.au Identifier:ACTRN12612000750886