Alterations of renal hemodynamics in unilateral ureteral obstruction mediated by activation of endothelin receptor subtypes.
作者： DARSHAN K. BHANGDIA , FREDERICK A. GULMI , SHYAN-YIH CHOU , UNNI M.M. MOOPPAN , HONG KIM
DOI: 10.1097/01.JU.0000081956.16457.67
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摘要: ABSTRACTPurpose: Unilateral ureteral obstruction (UUO) for 21 hours causes severe renal vasoconstriction. We examined the role of endothelin (ET)-A receptor in hemodynamic alterations induced by UUO.Materials and Methods: Hemodynamic clearance experiments were performed 3 groups anesthetized dogs. In group 1, 6 sham operated dogs received intrarenal infusion specific ET-A antagonist BQ-610 (Peninsula Laboratories, Inc., Belmont, California), followed nitric oxide synthase substrate L-arginine. 7 2 release 21-hour UUO was 5 L-arginine infusion.Results: caused marked decreases blood flow (RBF) glomerular filtration rate (GFR) compared with 1. 1 did not alter RBF or GFR. contrast, after led to a signif...
jurology.com 参考文章(21)
DIANE FELSEN, DAVID SCHULSINGER, STEVEN S. GROSS, FRANCIS Y. KIM, DONALD MARION, E. DARRACOTT VAUGHAN, Renal hemodynamic and ureteral pressure changes in response to ureteral obstruction: the role of nitric oxide. The Journal of Urology. ,vol. 169, pp. 373- 376 ,(2003) , 10.1016/S0022-5347(05)64130-4
E Gulbins, J Hoffend, A P Zou, M S Dietrich, K Schlottmann, A Cavarape, M Steinhausen, Endothelin and endothelium-derived relaxing factor control of basal renovascular tone in hydronephrotic rat kidneys. The Journal of Physiology. ,vol. 469, pp. 571- 582 ,(1993) , 10.1113/JPHYSIOL.1993.SP019830
Masaki Ihara, Takahiro Fukuroda, Toshihiko Saeki, Masaru Nishikibe, Katsuhisa Kojiri, Hiroyuki Suda, Mitsuo Yano, An endothelin receptor (ETA) antagonist isolated from Streptomyces misakiensis. Biochemical and Biophysical Research Communications. ,vol. 178, pp. 132- 137 ,(1991) , 10.1016/0006-291X(91)91789-F
Scott A. Kahn, Frederick A. Gulmi, Shyan-Yih Chou, Unni M.M. Mooppan, Hong Kim, Contribution of endothelin-1 to renal vasoconstriction in unilateral ureteral obstruction: reversal by verapamil. The Journal of Urology. ,vol. 157, pp. 1957- 1962 ,(1997) , 10.1016/S0022-5347(01)64909-7
B M Brenner, J L Troy, B J Ballermann, Endothelium-dependent vascular responses. Mediators and mechanisms. Journal of Clinical Investigation. ,vol. 84, pp. 1373- 1378 ,(1989) , 10.1172/JCI114309
V Kon, T Yoshioka, A Fogo, I Ichikawa, Glomerular actions of endothelin in vivo. Journal of Clinical Investigation. ,vol. 83, pp. 1762- 1767 ,(1989) , 10.1172/JCI114079
Aiji Sakamoto, Masashi Yanagisawa, Takeshi Sakurai, Yoh Takuwa, Hiromi Yanagisawa, Tomoh Masaki, Cloning and functional expression of human cDNA for the ETB endothelin receptor Biochemical and Biophysical Research Communications. ,vol. 178, pp. 656- 663 ,(1991) , 10.1016/0006-291X(91)90158-4
W E Yarger, D D Schocken, R H Harris, Obstructive nephropathy in the rat: possible roles for the renin-angiotensin system, prostaglandins, and thromboxanes in postobstructive renal function. Journal of Clinical Investigation. ,vol. 65, pp. 400- 412 ,(1980) , 10.1172/JCI109683
Hiroshi Arai, Seiji Hori, Ichiro Aramori, Hiroaki Ohkubo, Shigetada Nakanishi, Cloning and expression of a cDNA encoding an endothelin receptor Nature. ,vol. 348, pp. 730- 732 ,(1990) , 10.1038/348730A0
S. MONCADA, The 1991 Ulf von Euler Lecture:The l-arginine: nitric oxide pathway Acta Physiologica Scandinavica. ,vol. 145, pp. 201- 227 ,(1992) , 10.1111/J.1748-1716.1992.TB09359.X