Modelling Cooperative Tumorigenesis in Drosophila.
作者： Helena E. Richardson , Marta Portela
DOI: 10.1155/2018/4258387
关键词:
摘要: The development of human metastatic cancer is a multistep process, involving the acquisition several genetic mutations, tumour heterogeneity, and interactions with surrounding microenvironment. Due to complexity in mammals, simpler model organisms, such as vinegar fly, Drosophila melanogaster, are being utilized provide novel insights into molecular mechanisms involved. In this review, we highlight recent advances modelling tumorigenesis using model, focusing on cooperation oncogenes or suppressors, interaction mutant cells tissue epithelial initiation progression.
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Lina M. Rodahl, Kaisa Haglund, Catherine Sem-Jacobsen, Franz Wendler, Jean-Paul Vincent, Karine Lindmo, Tor Erik Rusten, Harald Stenmark, Disruption of Vps4 and JNK Function in Drosophila Causes Tumour Growth PLoS ONE. ,vol. 4, pp. e4354- ,(2009) , 10.1371/JOURNAL.PONE.0004354
Teresa Palomero, Maria Luisa Sulis, Maria Cortina, Pedro J Real, Kelly Barnes, Maria Ciofani, Esther Caparros, Jean Buteau, Kristy Brown, Sherrie L Perkins, Govind Bhagat, Archana M Agarwal, Giuseppe Basso, Mireia Castillo, Satoru Nagase, Carlos Cordon-Cardo, Ramon Parsons, Juan Carlos Zúñiga-Pflücker, Maria Dominguez, Adolfo A Ferrando, Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia Nature Medicine. ,vol. 13, pp. 1203- 1210 ,(2007) , 10.1038/NM1636
Marco Milán, Marta Clemente-Ruiz, Andrés Dekanty, Mariana Muzzopappa, Aneuploidy and tumorigenesis in Drosophila. Seminars in Cell & Developmental Biology. ,vol. 28, pp. 110- 115 ,(2014) , 10.1016/J.SEMCDB.2014.03.014
Sergio Casas-Tinto, Miguel Torres, Eduardo Moreno, The flower code and cancer development. Clinical & Translational Oncology. ,vol. 13, pp. 5- 9 ,(2011) , 10.1007/S12094-011-0610-4
Audrey E. Christiansen, Tian Ding, Andreas Bergmann, Ligand-independent activation of the Hedgehog pathway displays non-cell autonomous proliferation during eye development in Drosophila Mechanisms of Development. ,vol. 129, pp. 98- 108 ,(2012) , 10.1016/J.MOD.2012.05.009
Tatsushi Igaki, Correcting developmental errors by apoptosis: lessons from Drosophila JNK signaling Apoptosis. ,vol. 14, pp. 1021- 1028 ,(2009) , 10.1007/S10495-009-0361-7
Hillary K. Graves, Sarah E. Woodfield, Chih-Chao Yang, Georg Halder, Andreas Bergmann, Notch Signaling Activates Yorkie Non-Cell Autonomously in Drosophila PLoS ONE. ,vol. 7, pp. e37615- ,(2012) , 10.1371/JOURNAL.PONE.0037615
Alicia E. Rosales-Nieves, Acaimo González-Reyes, Genetics and mechanisms of ovarian cancer: parallels between Drosophila and humans. Seminars in Cell & Developmental Biology. ,vol. 28, pp. 104- 109 ,(2014) , 10.1016/J.SEMCDB.2014.03.031
Marcos Vidal, The dark side of fly TNF: an ancient developmental proof reading mechanism turned into tumor promoter. Cell Cycle. ,vol. 9, pp. 3851- 3856 ,(2010) , 10.4161/CC.9.19.13280
Tirtha K. Das, Ross L. Cagan, A Drosophila approach to thyroid cancer therapeutics Drug Discovery Today: Technologies. ,vol. 10, ,(2013) , 10.1016/J.DDTEC.2012.09.004