Increase of Fucosylated Serum Cholinesterase in Relation to High Risk Groups for Hepatocellular Carcinomas

摘要: Abstract Serum cholinesterase (ChE) (E.C. 3.1.1.8) is a glycoprotein which has 36 potential sites of asparagine-N-linked sugar chains. The structures oligosaccharides released from ChE on hydrazinolysis were studied by serial lectin affinity column chromatography, exoglycosidase digestion, and methylation analysis. Seventy-three % the chains occurred as biantennary remainder C-2 C-2,4/C-2,6 branched tri- tetraantennary oligosaccharides. Several percentages Lewis X antigenic determinant fucosylated mannose core linked to them, their sialic acid residues nonreducing terminal galactose at C-3 C-6 positions. Aleuria aurantia lectin-reactive with increased in hepatocellular carcinomas liver cirrhosis compared chronic hepatitis; other hand, did not change significantly after transcatheter arterial embolization was related serum levels α-fetoprotein carcinoembryonic antigen patients carcinomas. Accordingly, analysis clinically useful for differentiating hepatitis identify high risk groups carcinomas, i.e., cirrhotic Child9s A grade. costs publication this article defrayed part payment page charges. This must therefore be hereby marked advertisement accordance 18 U.S.C. Section 1734 solely indicate fact.