Effect of platelet-rich plasma on bone healing of fresh frozen bone allograft in mandibular defects: a histomorphometric study in dogs.
作者： Michel R Messora , Maria JH Nagata , Natália M Pola , Natália de Campos , Stephen E Fucini
DOI: 10.1111/CLR.12008
关键词:
摘要: Objective This study histologically analyzed the healing of fresh frozen bone allograft (FFBA) with or without platelet-rich plasma (PRP) in bony defects surgically created mandible dogs. Material and methods Bilateral resection were on inferior border 10 dogs. The randomly divided into three groups: C (the defect was filled by blood clot only), FFBA particulate FFBA), FFBA/PRP combined PRP). animals euthanized at 12 weeks post-surgery. Histomorphometric histological analyses performed. Data statistically using Friedman test Dunn (P < 0.05). Results Group presented a greater mineralized area smaller marrow than Groups C. Conclusions The use PRP improved incorporation FFBA, increasing density newly formed
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