Neurochemical correlates of alcohol preference in inbred strains of mice
作者： A.K.S. Ho , C.S. Tsai , B. Kissin
DOI: 10.1016/0091-3057(75)90019-2
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摘要: C5 7B16J, a specific inbred strain of mice with high alcohol preference and DBA/2J, poor for were studied. Brain content acetylcholine, uptake 14C-Choline by whole brain homogenate significantly higher in the 7B16J whereas acetylcholinesterase was DBA/2J mice. No significant difference found level serotonin, 3H-norepinephrine or 3H-dopamine. Treatment inhibitor choline transferase, 4-(1-napthylvinyl) pyridine salt (10 mg/kg, twice daily) shifted selection to water These findings suggest direct involvement central cholinergic mechanism preference.
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sci-hub.se 参考文章(17)
A. K. S. Ho, G. Singer, S. Gershon, Biochemical evidence of adrenergic interaction with cholinergic function in the central nervous system of the rat Psychopharmacology. ,vol. 21, pp. 238- 246 ,(1971) , 10.1007/BF00403862
Nobin A, Björklund A, Baumgarten Hg, Lachenmayer L, Stenevi U, Long-lasting selective depletion of brain serotonin by 5,6-dihydroxytryptamine. Acta Physiologica Scandinavica. ,vol. 373, pp. 1- 15 ,(1971)
Catherine Hebb, Formation, Storage, and Liberation of Acetylcholine Springer Berlin Heidelberg. pp. 55- 88 ,(1963) , 10.1007/978-3-642-99875-1_3
David A. Rodgers, Gerald E. McClearn, Mouse Strain Differences in Preference for Various Concentrations of Alcohol Quarterly journal of studies on alcohol. ,vol. 23, pp. 26- 33 ,(1962) , 10.15288/QJSA.1962.23.026
VP Whittaker, IA Michaelson, RJA Kirkland, The separation of synaptic vesicles from nerve-ending particles ('synaptosomes'). Biochemical Journal. ,vol. 90, pp. 293- 303 ,(1964) , 10.1042/BJ0900293
A. Lewis Farr, Oliver H. Lowry, Rose J. Randall, Nira J. Rosebrough, Protein Measurement with the Folin Phenol Reagent Journal of Biological Chemistry. ,vol. 193, pp. 265- 275 ,(1951)
Irving Geller, Effects of para-chlorophenylalanine and 5-hydroxytryptophan on alcohol intake in the rat Pharmacology Biochemistry and Behavior. ,vol. 1, pp. 361- 365 ,(1973) , 10.1016/0091-3057(73)90130-5
R. D. Myers, W. L. Veale, Alcohol Preference in the Rat: Reduction Following Depletion of Brain Serotonin Science. ,vol. 160, pp. 1469- 1471 ,(1968) , 10.1126/SCIENCE.160.3835.1469
R. E. MCCAMAN, J. M. HUNT, MICRODETERMINATION OF CHOLINE ACETYLASE IN NERVOUS TISSUE. Journal of Neurochemistry. ,vol. 12, pp. 253- 259 ,(1965) , 10.1111/J.1471-4159.1965.TB06762.X
G.B. Ansell, M.F. Beeson, A rapid and sensitive procedure for the combined assay of noradrenaline, dopamine, and serotonin in a single brain sample Analytical Biochemistry. ,vol. 23, pp. 196- 206 ,(1968) , 10.1016/0003-2697(68)90351-5