ON THE UNLIKELIHOOD OF SPECIFIC LONG RANGE FORCES IN IMMUNOLOGIC AND ENZYMATIC REACTIONS

摘要: In the past few years, a great many experiments have been performed by Rothen (24, 25) which he has interpreted as suggesting that antigen and antibody, enzyme substrate proteins, can react specifically, although separated distances of hundreds angstroms. This hypothesis seems to conflict with evidence accumulated from other investigations indicating short range interactions, involving usually associated electrostatic van der Waals’ forces, hydrogen bonds, order 5 A, operate in these reactions. We therefore engaged critical analysis experimental techniques used determine whether some interpretation than invoking existence specific long forces could be found explain his results.