Obese-insulin resistance accelerates and aggravates cardiometabolic disorders and cardiac mitochondrial dysfunction in estrogen-deprived female rats.

摘要: Women have a lower incidence of cardiovascular diseases (CVD) than men at similar age but an increased CVD and metabolic syndrome after menopause, indicating the possible protective effects estrogen on cardiometabolic function. Although obesity is known to increase risks, its impact heart deprivation still inconclusive. We investigated obese-insulin resistance function in estrogen-deprived ovariectomized rats. Adult female (O) or sham (S)-operated rats randomly received either normal diet (ND, 19.77 % fat) high-fat (HF, 57.60 (n = 6/group) for 12 weeks. The rate variability (HRV), left ventricular (LV) performance, cardiac autonomic balance, mitochondrial function, parameters, oxidative stress, apoptotic markers were determined 4, 8, Insulin developed week 8 NDO, HFS, HFO as indicated by plasma insulin HOMA index. However, only had elevated cholesterol level whereas HFS showed elevation 12. In addition, depressed HRV, impaired LV performance decreased fractional shortening (%FS) dysfunction ROS level, depolarization swelling, early other groups exhibited them Either alone may impair obese insulin-resistant condition further accelerated aggravated development these impairments