Immunoassays for trifloxystrobin analysis. Part I. Rational design of regioisomeric haptens and production of monoclonal antibodies.
作者： Rosario López-Moreno , Josep V. Mercader , Consuelo Agulló , Antonio Abad-Somovilla , Antonio Abad-Fuentes
DOI: 10.1016/J.FOODCHEM.2013.11.150
关键词:
摘要: Abstract Trifloxystrobin is one of the main active principles belonging to strobilurin family crop protection compounds. In this article, synthesis a battery regioisomeric functionalized derivatives trifloxystrobin described. The same aliphatic linear carboxylated chain was introduced as spacer arm in all synthesized haptens, but it located at different positions parent molecule. N , ′-Disuccinimidyl carbonate employed for hapten activation, so resulting -hydroxysuccinimyl ester could be readily purified and efficiently coupled proteins. After immunization hybridoma generation, collection 20 mouse monoclonal antibodies from immunizing haptens obtained. analytical performance these immunoreagents evaluated terms affinity selectivity with aim develop rapid practical immunochemical procedures determination.
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