Improvement of platelet counts in steroid-unresponsive idiopathic immune thrombocytopenic purpura after short-course therapy with recombinant alpha 2b interferon

摘要: In 13 patients with severe steroid-refractory idiopathic immune thrombocytopenia (ITP), a short course of recombinant alpha 2b interferon (IFN), given at dose 3 MU for 12 doses, caused significant increase in platelet count 11 patients. The rise occurred following completion the IFN 10 and during therapy one patient. Three showed an to normal counts within 14 days discontinuing drug, eight partial response, from 30 100 x 10(9)/L, two minimal response. One complete responder relapsed 5 months initial further second prompt response supranormal levels. Short-course can be recommended as ITP. Responses are seen splenectomized nonsplenectomized subjects, is not exacerbated treatment.