The impact of insight in a first-episode mania with psychosis population on outcome at 18 months

摘要: Abstract Background To explore whether poor initial insight during a first episode of mania with psychotic features was predictive psychosocial and clinical outcomes at 18 months. Methods Secondary analysis performed on data collected an 8-week RCT comparing the efficacy olanzapine versus chlorpromazine as adjunct to lithium, 18-month follow-up. 74 participants were divided into three groups (no insight, partial full insight) according item from Young Mania Rating Scale (YMRS). Differences between these examined baseline months measures symptoms (YMRS, HAMD-21, CGI-S), social occupational functioning (SOFAS). Baseline differences determined using general linear models chi-squared analyses. Group follow-up repeated models. Results At there significant in terms functioning, but all had improved significantly psychopathology, mania, depression functioning. There no study completion respect domains. Limitations The limited by lack availability more detailed rating scale for it did not account duration untreated psychosis (DUI). Conclusions Poor does predict outcome