Prevalence of and outcomes associated with corticosteroid prescription in inflammatory bowel disease.

摘要: Background Corticosteroids are widely used in the management of inflammatory bowel disease (IBD) and associated with significant side effects. The real world effectiveness newer drug therapies at reducing corticosteroid use is yet to be reported. overall burden poorly characterized. Methods We a population-based IBD database evaluate prevalence exposure, corticosteroid-free survival, heavy (≥3000 mg prednisone or equivalent 365-day period). Regression models were assess predictors relationship between dose first year after diagnosis need for continued surgery. Results proportion persons prescribed corticosteroids within 1, 5, 10 years was 35.2%, 52.0%, 62.8%, respectively. Persons ulcerative colitis, males, before age 25 more likely have higher cumulative exposure. Heavy 3 times increased hazard resective Cumulative exposure did not decrease among those diagnosed recent years, despite increasing immunomodulators. Conclusions A plurality patients will exposed over course disease, mostly year. strong predictor subsequent decreasing uptake