Developmental regulation of interstitial cell density in bullfrog skeletal muscle

摘要: Denervation of skeletal muscle results in striking connective tissue remodelling junctional areas muscle. Since extracellular matrix molecules mediate axonal growth and synaptic differentiation, it is likely that the interstitial cells accumulate near sites after denervation influence regrowth regeneration connections. The experiments presented here addressed question whether developing bullfrog was also specialized its cellular molecular composition. responses muscle, such as extrajunctional sensitivity to acetylcholine, often reproduce characteristics during synaptogenesis. In distribution nonuniform period fibre birth Interstitial were concentrated denervated adult Unlike there no accumulations fibronectin or tenascin, produced by cells, muscles. These demonstrate identified a high density may play role identification formation sites. Further, environment distinct from occurs response denervation, suggesting production development regulated differently neuromuscular junction.