Interaction of antibacterial compounds with RND efflux pumps in Pseudomonas aeruginosa

摘要: Pseudomonas aeruginosa infections are becoming increasingly difficult to treat due intrinsic antibiotic resistance and the propensity of this pathogen accumulate diverse mechanisms. Hyperexpression efflux pumps Resistance-Nodulation-Division-type multidrug (e.g. MexAB-OprM), chromosomally encoded by mexAB-oprM, mexCD-oprJ, mexEF-oprN, mexXY (-oprA) is often detected in clinical isolates contributes worrying multi-drug phenotypes. Not all antibiotics affected same extent aforementioned RND pumps. The impact on activity varies not only between different classes but also members family antibiotics. Subtle differences physicochemical features compound-pump compound-solvent interactions largely determine how compounds activity. combination high-resolution techniques helps gain insight into functioning these molecular machineries. This review discusses substrate recognition patterns based experimental evidence computer simulations with a focus MexB, pump subunit main transporter P. aeruginosa.