Mechanisms of Varicella-Zoster Virus Neuropathogenesis in Human Dorsal Root Ganglia
作者： Mike Reichelt , Leigh Zerboni , Ann M. Arvin
DOI: 10.1128/JVI.02592-07
关键词:
摘要: Varicella-zoster virus (VZV) is a human alphaherpesvirus that infects sensory ganglia and reactivates from latency to cause herpes zoster. VZV replication was examined in dorsal root ganglion (DRG) xenografts mice with severe combined immunodeficiency using multiscale correlative immunofluorescence electron microscopy. These experiments showed the presence of genomic DNA, viral proteins, virion production both neurons satellite cells within DRG. Furthermore, analysis VZV-host cell interactions revealed virus-induced cell-cell fusion polykaryon formation between during DRG vivo. Satellite infection neuron-satellite complexes provide mechanisms amplify entry into neuronal bodies, which necessary for transfer skin affected dermatome neuropathogenesis help account often neurologic consequences
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