Diagnostic ultrastructural pathology--sub-speciality or special stain?

摘要: The high resolving power of the electron microscopy gives ultrastructural pathology many features a 'sensitive, multipurpose stain'. But resolution rise to problems evaluation since most pathological disease are specific in quantitative rather than qualitative way. Thus, changes may be diagnostic importance when they severe enough seen by light microscopy, but less so only revealed microscopy. Problems and interpretation should not lead paralysing nihilism make us realize that does represent ignorant pathologist's key heaven, no more do special stains, histochemistry immunocytochemistry. At present it necessary organize as kind sub-speciality pathology. In long run, we feel sub-specialities related object studied instrument used. neuropathologist neuropathology, cytologist cytopathology, etc. same way kidney pathologists already their own work.