WNT signaling in bone homeostasis and disease: from human mutations to treatments

作者: Roland Baron , Michaela Kneissel

DOI: 10.1038/NM.3074

关键词:

摘要: … to glucose and energy metabolism 25 and fertility 26 . … WNT signaling represses mesenchymal stem cell (MSC) … development affects osteoblast differentiation substantially 29 , …

参考文章(226)
Frederick S. Kaplan, Petra Seemann, Julia Haupt, Meiqi Xu, Vitali Y. Lounev, Mary Mullins, Eileen M. Shore, Investigations of activated ACVR1/ALK2, a bone morphogenetic protein type I receptor, that causes fibrodysplasia ossificans progressiva. Methods in Enzymology. ,vol. 484, pp. 357- 373 ,(2010) , 10.1016/B978-0-12-381298-8.00018-6
Andreas Jenny, Planar cell polarity signaling in the Drosophila eye. Current Topics in Developmental Biology. ,vol. 93, pp. 189- 227 ,(2010) , 10.1016/B978-0-12-385044-7.00007-2
Eric Bourhis, Christine Tam, Yvonne Franke, J. Fernando Bazan, James Ernst, Jiyoung Hwang, Mike Costa, Andrea G. Cochran, Rami N. Hannoush, Reconstitution of a Frizzled8-Wnt3a-LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6 Journal of Biological Chemistry. ,vol. 285, pp. 9172- 9179 ,(2010) , 10.1074/JBC.M109.092130
Minke E Binnerts, Kyung-Ah Kim, Jessica M Bright, Sejal M Patel, Karolyn Tran, Mei Zhou, John M Leung, Yi Liu, Woodrow E Lomas III, Melissa Dixon, Sophie A Hazell, Marie Wagle, Wen-Sheng Nie, Nenad Tomasevic, Jason Williams, Xiaoming Zhan, Michael D Levy, Walter D Funk, Arie Abo, R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6 Proceedings of the National Academy of Sciences of the United States of America. ,vol. 104, pp. 14700- 14705 ,(2007) , 10.1073/PNAS.0702305104
Yong-Ri Jin, Taryn J. Turcotte, Alison L. Crocker, Xiang Hua Han, Jeong Kyo Yoon, The canonical Wnt signaling activator, R-spondin2, regulates craniofacial patterning and morphogenesis within the branchial arch through ectodermal-mesenchymal interaction. Developmental Biology. ,vol. 352, pp. 1- 13 ,(2011) , 10.1016/J.YDBIO.2011.01.004
Wen-Feng Li, Shu-Xun Hou, Bin Yu, Meng-Meng Li, Claude Férec, Jian-Min Chen, Genetics of osteoporosis: accelerating pace in gene identification and validation Human Genetics. ,vol. 127, pp. 249- 285 ,(2010) , 10.1007/S00439-009-0773-Z
Benjamin P Sinder, Mary M Eddy, Michael S Ominsky, Michelle S Caird, Joan C Marini, Kenneth M Kozloff, Sclerostin antibody improves skeletal parameters in a Brtl/+ mouse model of osteogenesis imperfecta Journal of Bone and Mineral Research. ,vol. 28, pp. 73- 80 ,(2013) , 10.1002/JBMR.1717
Ina Kramer, Hansjoerg Keller, Olivier Leupin, Michaela Kneissel, Does osteocytic SOST suppression mediate PTH bone anabolism Trends in Endocrinology and Metabolism. ,vol. 21, pp. 237- 244 ,(2010) , 10.1016/J.TEM.2009.12.002
Su Jin Kim, Tadeusz Bieganski, Young Bae Sohn, Kazimierz Kozlowski, Mikhail Semënov, Nobuhiko Okamoto, Chi Hwa Kim, Ah-Ra Ko, Geung Hwan Ahn, Yoon-La Choi, Sung Won Park, Chang-Seok Ki, Ok-Hwa Kim, Gen Nishimura, Sheila Unger, Andrea Superti-Furga, Dong-Kyu Jin, Identification of signal peptide domain SOST mutations in autosomal dominant craniodiaphyseal dysplasia Human Genetics. ,vol. 129, pp. 497- 502 ,(2011) , 10.1007/S00439-011-0947-3
Elizabeth A. Streeten, Daniel McBride, Eric Puffenberger, Marc E. Hoffman, Toni I. Pollin, Patrick Donnelly, Paul Sack, Holmes Morton, Osteoporosis-pseudoglioma syndrome: Description of 9 new cases and beneficial response to bisphosphonates Bone. ,vol. 43, pp. 584- 590 ,(2008) , 10.1016/J.BONE.2008.04.020