Frequent chromosomal aberrations and candidate genes in head and neck squamous cell carcinoma
作者： Krzysztof Szyfter , Malgorzata Wierzbicka , Jennifer L. Hunt , Alessandra Rinaldo , Juan P. Rodrigo
DOI: 10.1007/S00405-014-3339-1
关键词:
摘要: The knowledge of the biology head and neck squamous cell carcinoma (HNSCC) has had relatively little impact on improvement in oncologic outcome up to date. However, identification oncogenes tumor suppressor genes (TSGs) involved cancer progression contributes understanding molecular pathways oncogenesis could contribute individual risk assessment provide tools for treatment targets therapy based alterations these pathways. aim this article is review chromosomal aberrations commonly found HNSCC, identify regions suggested act as (candidate) or TSGs, discuss mechanisms modulating their expression.
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