Potential phytochemicals in the prevention and treatment of esophagus cancer: A green therapeutic approach.
作者： Banzeer Ahsan Abbasi , Javed Iqbal , Riaz Ahmad , Sitara Bibi , Tariq Mahmood
DOI: 10.1016/J.PHAREP.2019.03.001
关键词:
摘要: Globally, esophagus cancer (EC) is one of the most frequently reported malignancies and leading cause deaths. Currently, different treatment methods are available like chemotherapy, radiation therapy, surgery or their combination. These strategies not enough often associated with adverse side effects. The alternate option phytochemicals have come up ease bioavailability cost-effectiveness. Due to general acceptance, lower effects, safety pleiotropic effect, can be used as an adjuvant for alleviating effects chemotherapy radiotherapy. Phytochemicals perform multiple functions; release cytochrome-c, loss mitochondrial membrane potential, down-regulate expression anti-apoptotic proteins, up-regulate pro-apoptotic activate caspases, p53, inhibit Akt/mTOR signaling pathway, phosphorylate NF-κB, STAT3 PI3K. knowledge compiled here encompasses anti-EC phytochemicals, occurrence, therapeutic mechanism action by targeting several genes pathways. Overall, clinical data on against EC sufficient need future research provide additional insights developing potential anticancer drugs in pharma industries.
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sci-hub.se 参考文章(113)
Ashok L, Anand L, Chitra S, Srinivasan, Jayanthi, Risk factors for esophageal cancer in Coimbatore, southern India: a hospital-based case-control study. Indian Journal of Gastroenterology. ,vol. 23, pp. 19- 21 ,(2004)
M. Muzaffar Mir, Nazir Ahmad Dar, Esophageal Cancer in Kashmir (India): An Enigma for Researchers International journal of health sciences. ,vol. 3, pp. 71- 85 ,(2009)
Feng-Juan Zhang, Hong-Sheng Zhang, Yang Liu, Ying-Hui Huang, Curcumin inhibits Ec109 cell growth via an AMPK-mediated metabolic switch. Life Sciences. ,vol. 134, pp. 49- 55 ,(2015) , 10.1016/J.LFS.2015.05.016
Shu Yan, Shuxia Tian, Qingwei Kang, Yafei Xia, Caixia Li, Qing Chen, Shukun Zhang, Zhigang Li, Rhizoma Paridis Saponins Suppresses Tumor Growth in a Rat Model of N-Nitrosomethylbenzylamine-Induced Esophageal Cancer by Inhibiting Cyclooxygenases-2 Pathway PLOS ONE. ,vol. 10, pp. e0131560- ,(2015) , 10.1371/JOURNAL.PONE.0131560
Jun Liu, Jian Wang, Ye Leng, Changxing Lv, Intake of fruit and vegetables and risk of esophageal squamous cell carcinoma: A meta‐analysis of observational studies International Journal of Cancer. ,vol. 133, pp. 473- 485 ,(2013) , 10.1002/IJC.28024
Guy D. Eslick, Epidemiology of Esophageal Cancer Gastroenterology Clinics of North America. ,vol. 38, pp. 17- 25 ,(2009) , 10.1016/J.GTC.2009.01.008
Wen Li, Min Wang, Lingyun Wang, Shusheng Ji, Junyong Zhang, Chunqing Zhang, Icariin synergizes with arsenic trioxide to suppress human hepatocellular carcinoma. Cell Biochemistry and Biophysics. ,vol. 68, pp. 427- 436 ,(2014) , 10.1007/S12013-013-9724-3
Miki Kawada, Yasushi Ohno, Yunmo Ri, Tetsuro Ikoma, Hideyuki Yuugetu, Toshihiro Asai, Motohiro Watanabe, Norio Yasuda, Seigou Akao, Genzou Takemura, Shinya Minatoguchi, Kohshi Gotoh, Hisayoshi Fujiwara, Kazunori Fukuda, Anti-tumor effect of gallic acid on LL-2 lung cancer cells transplanted in mice. Anti-Cancer Drugs. ,vol. 12, pp. 847- 852 ,(2001) , 10.1097/00001813-200111000-00009
T. W. Kok, Patrick Y. K. Yue, N. K. Mak, T. P. D. Fan, L. Liu, Ricky N. S. Wong, The anti-angiogenic effect of sinomenine. Angiogenesis. ,vol. 8, pp. 3- 12 ,(2005) , 10.1007/S10456-005-2892-Z
Jeffrey H. Peters, N. Avisar, The Molecular Pathogenesis of Barrett’s Esophagus: Common Signaling Pathways in Embryogenesis Metaplasia and Neoplasia Journal of Gastrointestinal Surgery. ,vol. 14, pp. 81- 87 ,(2010) , 10.1007/S11605-009-1011-7