Geographical ancestry affects normal hemoglobin values in high-altitude residents.

摘要: Increasing the hemoglobin (Hb) concentration is a major mechanism adjusting arterial oxygen content to decreased partial pressure of inspired air at high altitude. Approximately 5% world's population living altitudes higher than 1,500 m shows this adaptive mechanism. Notably, there wide variation in extent increase Hb among different populations. This short review summarizes available information on concentrations high-altitude residents comparable (3,500-4,500 m) regions world. An increased found all The highest mean was adult male Andean and Han Chinese altitude, whereas it lowest Ethiopians, Tibetans, Sherpas. A lower plasma volume natives may offer explanation. Indeed, have Tibetans Ethiopians. Moreover, values were adult, nonpregnant females males; differences between populations ancestry less pronounced. Various genetic polymorphisms detected thought favor life hypoxic environment, some which correlate with relatively low angiotensin-converting enzyme allele distribution be related elevated Andeans. Taken together, these results indicate sensitivity dependent control erythropoiesis or geographical ancestry, offering explanations for