Exosome secretome and mediated signaling in breast cancer patients with nontuberculous mycobacterial disease

摘要: // Julie V. Philley 1 , Anbarasu Kannan 2 David E. Griffith Megan S. Devine Jeana L. Benwill Richard J. Wallace, Jr. 1, 3 Barbara A. Brown-Elliott Foram Thakkar Varsha Taskar James G. Fox Ammar Alqaid Hernaina Bains Sudeep Gupta 4 Santanu Dasgupta Departments of Medicine, The University Texas Health Science Center at Tyler, Texas, USA Cellular and Molecular Biology, Mycobacteria/Nocardia Research Laboratory Department Microbiology, Medical Oncology, Tata Memorial Center, Mumbai, India Correspondence to: Dasgupta, email: santanu.dasgupta@uthct.edu Keywords: Exosomes, breast cancer, nontuberculous Mycobacterium, ECM1, biomarker Received: July 10, 2016     Accepted: January 2017     Published: February 01, 2017 ABSTRACT Bronchiectasis Nontuberculous mycobacterium (NTM nb ) infection is an emerging health problem in cancer (BCa) patients. We measured sera exosome proteome BCa-NTM subjects controls by Mass Spectroscopy. Extracellular matrix protein (ECM1) was detected exclusively the circulating exosomes 82% cases. Co-culture ECM1 + with normal human mammary epithelial cells induced to mesenchymal transition accompanied increased Vimentin/CDH1 expression ratio Glutamate production. T modulated their cytokine were markedly higher obtained from subjects. Exclusive APN, APOC4 AZGP1 evident these cases, which predicts disease prevalence independent body max index concert ECM1. Monitoring could be beneficial for risk assessment, monitoring surveillance .