Toxic effects induced by curcumin in human astrocytoma cell lines.
作者： Mirna A. Romero-Hernández , Pilar Eguía-Aguilar , Mario Perézpeña-DiazConti , Alejandra Rodríguez-Leviz , Stanislaw Sadowinski-Pine
DOI: 10.3109/15376516.2013.826768
关键词:
摘要: AbstractObjective: The objective of this study was to describe the toxicity induced by curcumin in human astrocytoma cell lines.Methods: effects curcumin, at 100 µM for 24 h, were evaluated four lines using crystal violet assay and through evaluation morphological ultrastructural changes electron microscopy. Also, results vital staining with acridine orange propidium iodide acidic vesicles apoptotic bodies analyzed expression Beclin1 gene assessed RT-PCR.Results: cells treated an inhibitory concentration50 viability characterized a progressive increase large, non-acidic devoid cytoplasmic components organelles, but that conserved nuclei. No DNA breakage observed. showed no apoptosis, necrosis or autophagy. Expression BECLIN1 not (p < 0.05) cells....
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