作者: Xian-Hao Peng , Xiang Fang , Joan M. Lappe , Robert R. Recker , Peng Xiao
DOI: 10.1371/JOURNAL.PONE.0034641
关键词:
摘要: Background Osteoporosis mainly occurs in postmenopausal women, which is characterized by low bone mineral density (BMD) due to unbalanced resorption osteoclasts and formation osteoblasts. Circulating monocytes play important roles osteoclastogenesis acting as osteoclast precursors secreting osteoclastogenic factors, such IL-1, IL-6 TNF-α. MicroRNAs (miRNAs) have been implicated biomarkers various diseases. The present study aimed find significant miRNA human circulating underlying osteoporosis. Methodology/Principal Findings We used ABI TaqMan® array followed qRT-PCR validation identify 10 high BMD Caucasian women. MiR-133a was upregulated (P=0.007) the compared with groups analyses, also validated (P=0.044). We performed bioinformatic target gene analysis found three potential osteoclast-related genes, CXCL11, CXCR3 SLC39A1. In addition, we Pearson correlation analyses between expression levels of miR-133a genes 20 did negative correlations all though not significant. Conclusions/Significance This first vivo novel osteoporosis. Our results suggest that a biomarker for