Pathology of experimental nerve compression

摘要: Acute, graded, nerve compression was applied to the sciatic nerves of 91 rats in whom an inflatable miniature Plexiglass device had been implanted thigh. The experiment designed study pathogenesis lesions entrapment syndrome. Under general anesthesia, external pressures 80 mm Hg, 30 Hg and 10 were used compress for 2 hours. Identical devices placed around contralateral but remained uninflated so that these could be as controls. Nerves excised at intervals 4 24 hours, 1, 2, 5, 6, 7, 10, 14, 28 days, full thickness transverse sections made from Araldite blocks. first pathologic change edema which observed all time points correlated with severity axonal injury. Axonal predominant exposed (7.5 +/- 1.9 fibers per high power microscopic field (HPF)) while compressed showed fewer damaged axons (2.6 1.4 HPF). Demyelination lesion subjected commonly present chamber uninflated. Electron microscopy revealed demyelination associated Schwann cell necrosis. topography fiber injury remarkable; subperineurial often after core fascicle unaffected. findings suggest local causes ischemia served by transperineurial vessels, severe causing damage, lesser degrees compressive are demyelination.