Modulators of viral transcription, and methods and compositions therewith

作者: Fatah Kashanchi

DOI:

关键词:

摘要: The present invention is directed to a process for inhibiting the replication of human immunodeficiency virus-1 (HIV-1), by contacting cell with at least one compound according Formula I. substituent groups R1, R2, R3, X, Y, Z, A and B are as defined above. Also contemplated method treating or preventing HIV-1 infection in subject, administering therapeutically effective amount I, well modulating activity cyclin dependent kinase (cdk) infected using I compound.

参考文章(4)
Laurent Meijer, Nassima Oumata, Florence Popowycz, Benoït Joseph, Hervé Galons, Pyrazolo[1,5-a]-1,3,5-triazine derivatives, preparation thereof, and therapeutic use thereof ,(2010)
Florence Popowycz, Guy Fournet, Cédric Schneider, Karima Bettayeb, Yoan Ferandin, Cyrile Lamigeon, Oscar M. Tirado, Silvia Mateo-Lozano, Vicente Notario, Pierre Colas, Philippe Bernard, Laurent Meijer, Benoît Joseph, Pyrazolo[1,5-a]-1,3,5-triazine as a purine bioisostere: access to potent cyclin-dependent kinase inhibitor (R)-roscovitine analogue. Journal of Medicinal Chemistry. ,vol. 52, pp. 655- 663 ,(2009) , 10.1021/JM801340Z
K Bettayeb, N Oumata, A Echalier, Y Ferandin, J A Endicott, H Galons, L Meijer, CR8, a potent and selective, roscovitine-derived inhibitor of cyclin-dependent kinases Oncogene. ,vol. 27, pp. 5797- 5807 ,(2008) , 10.1038/ONC.2008.191
Fatah Kashanchi, Treatment of autoimmune disorders ,(2002)