Barbiturate reversal of amino acid antagonism produced by convulsant agents.

摘要: THE hypnotic and anticonvulsant properties of pentobarbitone related barbiturates may be closely associated with the actions γ-aminobutyric acid (GABA)1–3, an inhibitory transmitter at both pre- postsynaptic receptors in mammalian central nervous system4. Pentobarbitone prolongs pre-5 postsynaptic3 inhibition as well hyperpolarising neurones2,3. Although it has been suggested that synaptic by delaying removal GABA from cleft3,6 a direct action on cannot excluded2. We have explored this possibility rat isolated sympathetic superior cervical ganglia preparation, which possesses analogous to those brain7, vivo single neurones brainstem. In these experiments pentobarbitone, amounts produced no apparent GABA-mimetic effects, reversed bicuculline methochloride (BMC), selective antagonist.